The importance of cholesterol and its essentiality is examined. Cholesterol is transported within the human organism by lipoproteins (chylomicrons , VLDL,LDL and HDL).The LDL considered “bad cholesterol” transport cholesterol from the liver to the other tissus for their needs; however the HDL, ”good cholesterol ” transport back cholesterol to the liver to be recycled .Therfore , cholesterol is rather good for its various functions in the organism , and its deficiency may lead to cellular damage , and a reduction in the synthesis of hormones such as testosterone and also vitamin D. Hypercholesterolemia should be considered an indicator of a health problem within the cells, that the organism is trying to fix by mobilizing cholesterol.

Key words : Cholesterol, essentiality, lipoproteins (LDL ,HDL)